582 research outputs found

    Library Search UX report summer 2016

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    During Summer 2016, Imperial College London's Library Information Systems team ran a round of user experience research into the information-seeking behaviour of undergraduate and postgraduate students with a specific focus on the use of the library catalogue and discovery interface. The purpose of the work was to understand user behaviours and preferences to target development of practical improvements to the Library Search interface

    How white is your UX practice?: inclusion and diversity in critical UX research

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    During summer 2016, Imperial College London’s Library Information Systems team ran user experience research into the information-seeking behaviour of undergraduate and postgraduate students focusing on the use of the library catalogue and discovery interface. We gathered some really interesting findings which are helping to inform our continued redesigning of Imperial’s Ex Libris Primo search and discovery software. Our results are available in reports online but in this paper we want to talk about what we did wrong, the limitations of our methodology, and the impact on our approach to inclusion and diversity in our UX work and our view of wider UX research in libraries

    Pengaruh Pendidikan Kesehatan Hipertensi terhadap Pengetahuan Lansia di Posyandu Lansia Kelurahan Manisrenggo

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    Keluarga memiliki peran yang begitu penting bagi lansia yang menderita hipertensi khususnya dalam pemberian diet. Peran tersebut antara lain membimbing dan memecahkan masalah sehingga pemberian diet pada lansia dengan hipertensi dapat dikelola dengan baik oleh keluarga. Adapun penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan perilaku keluarga dalam pemberian diet hipertensi pada lansia. Faktor-faktornya adalah pengetahuan, sikap, umur, jenis kelamin, pendidikan, ketersediaan fasilitas kesehatan, dan tenaga kesehatan. Penelitian ini bersifat deskriptif analisis kuantitatif dengan menggunakan cross sectional. Jumlah sampel dalam penelitian ini sebanyak 30 responden. Pengambilan sampel menggunakan total sampling. Instrumen yang digunakan dalam penelitian ini adalah dengan wawancara menggunakan kuesioner. Data dianalisis dengan menggunakan analisis univariat dan analisis bivariat. Hasil analisis bivariat menunjukkan bahwa (a) ada hubungan antara pengetahuan dengan perilaku keluarga dalam pemberian diet hipertensi pada lansia ; (b) ada hubungan antara sikap dengan perilaku keluarga dalam pemberian diet hipertensi pada lansia ; (c) ada hubungan antara umur dengan perilaku keluarga dalam pemberian diet hipertensi pada lansia; (d) tidak ada hubungan antara jenis kelamin dengan perilaku keluarga dalam pemberian diet hipertensi pada lansia; (e) tidak ada hubungan antara pendidikan dengan perilaku keluarga dalam pemberian diet hipertensi pada lansia; (f) tidak ada hubungan antara ketersediaan fasilitas kesehatan dengan perilaku keluarga dalam pemberian diet hipertensi pada lansia; (g) tidak ada hubungan antara tenaga kesehatan dengan perilaku keluarga dalam pemberian diet hipertensi pada lansia. Keluarga perlu menyadari tentang pentingnya perannya dalam menjaga atau memantau nutrisi yang diberikan pada lansia dengan hipertensi. Keluarga dan penderita hipertensi harus bekerja sama agar penderita hipertensi patuh menjalani diet rendah garam agar tekanan darah penderita hipertensi dapat terkontrol dengan baik. Pada penelitian ini bahwa tingkat Pengaruh Pendidikan Kesehatan terhadap Pengetahuan Lansia di Posyandu Lansia Kelurahan Manisrenggo sebelum kita melakukan penyuluhan pada lansia dari 23 responden memiliki kategori cukup atau 43% dari 23 responden yaitu 10 responden. Namun, setelah kita melakukan penyuluhan tentang pengaruh pendidikan kesehatan terhadap pengetahuan lansia mengalami kenaikan dari 43% kategori cukup menjadi 52% memiliki kategori baik yaitu 12 orang

    Modelling study to estimate the health burden of foodborne diseases: cases, general practice consultations and hospitalisations in the UK, 2009.

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    OBJECTIVE: To generate estimates of the burden of UK-acquired foodborne disease accounting for uncertainty. DESIGN: A modelling study combining data from national public health surveillance systems for laboratory-confirmed infectious intestinal disease (IID) and outbreaks of foodborne disease and 2 prospective, population-based studies of IID in the community. The underlying data sets covered the time period 1993-2008. We used Monte Carlo simulation and a Bayesian approach, using a systematic review to generate Bayesian priors. We calculated point estimates with 95% credible intervals (CrI). SETTING: UK, 2009. OUTCOME MEASURES: Pathogen-specific estimates of the number of cases, general practice (GP) consultations and hospitalisations for foodborne disease in the UK in 2009. RESULTS: Bayesian approaches gave slightly more conservative estimates of overall health burden (∼511 000 cases vs 566 000 cases). Campylobacter is the most common foodborne pathogen, causing 280 400 (95% CrI 182 503-435 693) food-related cases and 38 860 (95% CrI 27 160-55 610) GP consultations annually. Despite this, there are only around 562 (95% CrI 189-1330) food-related hospital admissions due to Campylobacter, reflecting relatively low disease severity. Salmonella causes the largest number of hospitalisations, an estimated 2490 admissions (95% CrI 607-9631), closely followed by Escherichia coli O157 with 2233 admissions (95% CrI 170-32 159). Other common causes of foodborne disease include Clostridium perfringens, with an estimated 79 570 cases annually (95% CrI 30 700-211 298) and norovirus with 74 100 cases (95% CrI 61 150-89 660). Other viruses and protozoa ranked much lower as causes of foodborne disease. CONCLUSIONS: The 3 models yielded similar estimates of the burden of foodborne illness in the UK and show that continued reductions in Campylobacter, Salmonella, E. coli O157, C. perfringens and norovirus are needed to mitigate the impact of foodborne disease

    Anatomy of the high-frequency ambient seismic wave field at the TCDP borehole.

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    International audienceThe Taiwan Chelungpu-fault Drilling Project (TCDP) installed a vertical seismic array between 950 and 1270 m depth in an active thrust fault environment. In this paper we analyze continuous noise records of the TCDP array between 1 and 16 Hz. We apply multiple array processing and noise correlation techniques to study the noise source process, properties of the propagation medium, and the ambient seismic wave field. Diurnal amplitude and slowness patterns suggest that noise is generated by cultural activity. The vicinity of the recording site to the excitation region, indicated by a narrow azimuthal distribution of propagation directions, leads to a predominant ballistic propagation regime. This is evident from the compatibility of the data with an incident plane wave model, polarized direct arrivals of noise correlation functions, and the asymmetric arrival shape. Evidence for contributions from scattering comes from equilibrated earthquake coda energy ratios, the frequency dependent randomization of propagation directions, and the existence of correlation coda waves. We conclude that the ballistic and scattered propagation regime coexist, where the first regime dominates the records, but the second is weaker yet not negligible. Consequently, the wave field is not equipartitioned. Correlation signal-to-noise ratios indicate a frequency dependent noise intensity. Iterations of the correlation procedure enhance the signature of the scattered regime. Discrepancies between phase velocities estimated from correlation functions and in-situ measurements are associated with the array geometry and its relative orientation to the predominant energy flux. The stability of correlation functions suggests their applicability in future monitoring efforts

    The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex.

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    The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can resist microtubule pulling forces. The chromosomal passenger complex (CPC) is abundantly localized to the inner centromeres and it is unclear whether it is involved in non-kinase activities that contribute to the generation of these unique chromatin properties. We find that the borealin subunit of the CPC drives phase separation of the CPC in vitro at concentrations that are below those found on the inner centromere. We also provide strong evidence that the CPC exists in a phase-separated state at the inner centromere. CPC phase separation is required for its inner-centromere localization and function during mitosis. We suggest that the CPC combines phase separation, kinase and histone code-reading activities to enable the formation of a chromatin body with unique biochemical activities at the inner centromere

    Progression of Hypertrophy and Myocardial Fibrosis in Aortic Stenosis: A Multicenter Cardiac Magnetic Resonance Study

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    Background: Aortic stenosis is accompanied by progressive left ventricular hypertrophy and fibrosis. We investigated the natural history of these processes in asymptomatic patients and their potential reversal post-aortic valve replacement (AVR).  Methods: Asymptomatic and symptomatic patients with aortic stenosis underwent repeat echocardiography and magnetic resonance imaging. Changes in peak aortic-jet velocity, left ventricular mass index, diffuse fibrosis (indexed extracellular volume), and replacement fibrosis (late gadolinium enhancement [LGE]) were quantified.  RESULTS: In 61 asymptomatic patients (43% mild, 34% moderate, and 23% severe aortic stenosis), significant increases in peak aortic-jet velocity, left ventricular mass index, indexed extracellular volume, and LGE mass were observed after 2.1±0.7 years, with the most rapid progression observed in patients with most severe stenosis. Patients with baseline midwall LGE (n=16 [26%]; LGE mass, 2.5 g [0.8–4.8 g]) demonstrated particularly rapid increases in scar burden (78% [50%–158%] increase in LGE mass per year). In 38 symptomatic patients (age, 66±8 years; 76% men) who underwent AVR, there was a 19% (11%–25%) reduction in left ventricular mass index (P<0.0001) and an 11% (4%–16%) reduction in indexed extracellular volume (P=0.003) 0.9±0.3 years after surgery. By contrast midwall LGE (n=10 [26%]; mass, 3.3 g [2.6–8.0 g]) did not change post-AVR (n=10; 3.5 g [2.1–8.0 g]; P=0.23), with no evidence of regression even out to 2 years.  Conclusions: In patients with aortic stenosis, cellular hypertrophy and diffuse fibrosis progress in a rapid and balanced manner but are reversible after AVR. Once established, midwall LGE also accumulates rapidly but is irreversible post valve replacement. Given its adverse long-term prognosis, prompt AVR when midwall LGE is first identified may improve clinical outcomes
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